Synthesis of multisubstituted pyrroles from doubly activated cyclopropanes using an iron-mediated oxidation domino reaction.

نویسندگان

  • Zhiguo Zhang
  • Wei Zhang
  • Junlong Li
  • Qingfeng Liu
  • Tongxin Liu
  • Guisheng Zhang
چکیده

An alternative route has been developed for the construction of multisubstituted pyrrole derivatives from readily available, doubly activated cyclopropanes and anilines using an iron-mediated oxidation domino reaction (i.e., sequential ring-opening, cyclization, and dehydrogenation reactions). This reaction uses readily available reactants and is tolerant of a broad range of substrates, with the desired products being formed in good to excellent yields.

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عنوان ژورنال:
  • The Journal of organic chemistry

دوره 79 22  شماره 

صفحات  -

تاریخ انتشار 2014